Policy1-Lynch simulates colorectal cancer (CRC) in Lynch Syndrome (LS) and non-LS carriers and includes a model of screening for LS in incident CRC cases to identify probands, a model of screening for LS in family members (i.e. predictive genetic testing), model of prophylaxis and surveillance (prophylactic surgery, colonoscopic surveillance) and model of invasive cancer (cancer treatment and survival). It is currently being further developed to model endometrial and ovarian cancers.