Policy1-Prostate simulates the natural history of prostate cancer, with an overlay of PSA testing, subsequent management and surveillance, and prostate cancer survival. It is designed to be a flexible tool to simulate the costs and impact of a range of PSA testing strategies, as well as to simulate the impact of prostate cancer diagnostic and treatment interventions, including the use of new technologies and treatments. Policy1-Prostate has been calibrated to NSW cancer registry cancer data and validated against published trial (ERSPC and PLCO) outcomes and observed incidence and mortality trends in Australia.